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URINE DRUG ANALYSIS

Drug analysis samples can be submitted in the gray stoppered tubes used for alcohol analysis, and/or bottles, containers, or equivalent.

The detection of drugs in a urine sample is determined by initial screening or presumptive tests.  These tests target compounds in a drug group rather than specific drugs.  Following a positive screening result on a sample, a second confirmatory test is performed.  This second test uses a different analytical technique to identify a specific drug compound. 

Randox Screening Drugs & Levels:

The “Screening of Drugs” lists the drug categories for DOA1+ & DOAV screening panels.  DOA1+ testing is performed on all urine samples requesting drug screen analysis (pre-log: TXUD).  Depending on specific agency requests, DOAV testing may be completed.  DOA1+ and DOAV panels are completed using a Randox Instrument.


Randox Screening Levels – DOA1+ (Urine Samples)
|
Drug Group:
2018 2017 2016 2015
Total Amphetamines
Amphetamine & Methamphetamine
≥ 595 ≥ 595 ≥ 596 ≥ 589
Barbiturates ≥ 100 ≥ 100 ≥ 100 ≥ 100
Benzodiazepines I ≥ 50 ≥ 50 ≥ 50 ≥ 50
Benzodiazepines II ≥ 20 ≥ 20 ≥ 50 ≥ 50
Methadone ≥ 150 ≥ 150 ≥ 150 ≥ 150
Opiates ≥ 2352 ≥ 2247 ≥ 2381 ≥ 2381
Cocaine Metabolites ≥ 177 ≥ 177 ≥ 181 ≥ 177
MDMA ≥ 609 ≥ 602 ≥ 610 ≥ 618
Marijuana Metabolites ≥ 61 ≥ 60 ≥ 62.5 ≥ 62
Tricyclics ≥ 50 ≥ 50 ≥ 50 ≥ 50
Buprenorphine ≥ 5 ≥ 5 ≥ 5 ≥ 5
PCP ≥ 31 ≥ 32 ≥ 32 ≥ 32


Confirmation of Drug Categories (Confirmations):


When a screening test is positive, a confirmatory test is performed to identify the drug.  “Confirmation of Drug Categories” lists drug compounds that are typically reported following this second, confirmatory test.


Amphetamines Confirmation (Urine Samples):
amphetamine
methamphetamine
3,4-methylenedioxyamphetamine (MDA)
3,4-methylenedioxymethamphetamine (MDMA)
Phentermine

Barbituates Confirmation (Urine Samples):
butalbital
secobarbital
butabarbital
amobarbital
hexobarbital
phenobarbital

Opiates Confirmation (Urine Samples):
6-MAM
buprenorphine
codeine
dihydrocodeine
fentanyl
hydrocodone
hydromorphone
meperidine
methadone
morphine
norbuprenorphine
norcodeine
norfentanyl
normorphine
oxycodone
oxymorphone
propoxyphene


Cannabinoids Confirmation (Urine Samples):

Common Name:
11-nor-9-carbody-delta-9-tetrahydrocannabinol metabolite of THC

Cocaine Confirmation (Urine Samples):

Common Name:
benzolyecgonine metabolite of cocaine
cocaine ---
ecgonine methyl ester metabolite of cocaine
ethylbenzoylecgonine Cocaethylene, a metabolite of cocaine

Benzodiazepines & Sleep Drugs (Urine Samples):


Common Name:
7-aminoclonazepam metabolite of clonazepam
7-aminoflurazepam metabolite of flurazepam
alphahydroxyalprazolam alprazolam metabolite
alphahydroxymidazolam metabolite of midazolam
alphahydroxytriazolam metabolite of triazolam
alprazolam Xanax
bromazepam  
chlordiazepoxide librium
clonazepam Klonopin
desalkyflurazepam metabolite of flurazepam
diazepam Valium
estazolam  
flunitrazepam rohypnol
flurazepam dalmane
halazepam  
hydroxyethylflurazepam metabolite of flurazepam
lorazepam Activan
midazolam versed
nordiazepam metabolite of diazepam, chloradiazepoxide & halazepam
oxazepam also a metabolite of temazepam & diazepam
temazepam also a metabolite of diazepam
traizolam halcion
zolpiclone lunesta
zopidem ambien



Target Compounds:

“Target compounds” provides a list of drugs for a special type of screening method employing an instrument called the LCMSMS.  Rather than drug categories, it focuses on drug compounds.  This screening test is used in cases of Drug Facilitated Sexual Assault and other toxicology cases with special drug requests and cases that require additional information for confirmation testing. 

Target Drugs Tested for in Toxicology (Urine Samples):    Last Updated: February 2017

1 2CB 70 Ethenzamide 139 Nitrazepam
2 2-oro-3-hydroxy LSD 71 Fenspiride 140 Norbuprenorphine
3 4-MePPP 72 Fentanyl 141 Norclomipramine
4 4-chloro-2,5-dimethoxyamphetamine (DOC) 73 Flecainide 142 Nordiazepam
5 5-methoxy-DALT 74 Flumazenil 143 Nordoxepin
6 6MAM 75 Flunitrazepam 144 Norfentanyl
7 7-aminoclonazepam 76 Fluoxetine 145 Norfluoxetine
8 7-aminoflunitrazepam 77 Fluphenazine 146 Norketamine
9 7-hydroxyquetiapine 78 Flurazepam 147 Normeperidine
10 4-fluormethamphetamine 79 Fluvoxamine 148 Norpropoxyphene
11 Acebutolol 80 Gabapentin 149 Norquetiapine
12 Acetylfentanyl 81 Haloperidol 150 Nortriptyline
13 alpha-PVP 82 Heroin 151 Norverapamil
14 Alprazolam 83 Hydrocodone 152 O-desmethylvenlafaxine
15 Amiodarone 84 Hydromorphone 153 Olanzapine
16 Amitriptylene 85 Hydroquinidine 154 Orphenadrine
17 Amoxapine 86 Hydroxyalprazolam 155 Oxazepam
18 Amphetamine 87 Hydroxyzine 156 Oxcarbazepine
19 Atenolol 88 Imipramine 157 Oxprenolol
20 Atropine 89 Indomethazin 158 Oxycodone
21 Benzoylecgonine 90 Isometheptene 159 Paracetamol
22 Benzylpiperazine 91 25-I-NBoMe 160 Paroxetine
23 Betaxolol 92 Ketamine 161 PCP
24 Bisoprolol 93 Labetolol 162 Pentadrone
25 Bromazepam 94 Lamotrigine 163 Perphenazine
26 Brompheniramine 95 Lidocaine 164 Pheniramine
27 Bupivacaine 96 Loprazolam 165 Phenothiazine(2)
28 Buprenorphine 97 Lorazepam 166 Phenotiazine (1)
29 Bupropion 98 Lormetazepam 167 Phenylpropanolamine (PPA)
30 Bupropion hydroxyl
metabolite
99 Loxapine 168 Phenytoin
31 Butorphanol 100 LSD 169 Pindolol
32 Caffeine 101 Maprotiline 170 Piroxicam
33 Carbamazepine 102 MBDB 171 Prazepam
34 Carbamazepine 10,11
epoxide
103 mCPP 172 Primidone
35 Carisoprodol 104 MDA 173 Procaine
36 Cathine 105 MDEA 174 Promethazine
37 Cathinone 106 MDMA 175 Propafenone
38 Chlordiazepoxide 107 MDPV 176 Propanolol
39 Chloroquine 108 Meloxicam 177 Propoxyphene
40 Chlorpheniramine 109 Meperidine 178 Pseudoephedrine
41 Chlorpromazine 110 Mephedrone 179 Quetiapine
42 Citalopram 111 Meprobamate 180 Quinidine
43 Clenbuterol 112 Mescaline 181 Reserpine
44 Clobazam 113 Methadone 182 Risperidone
45 Clomipramine 114 Methamphetamine 183 Salbutamol
46 Clonazepam 115 Methaqualone 184 Scopolamine
47 Clonidine 116 Methedrone 185 Sertraline
48 Clozapine 117 Methocarbamol 186 Strychnine
49 Cocaine 118 Methyl Clonazepam 187 Sundilac
50 Codeine 119 Methylhexanamine 188 Tapentaldol
51 Colchicine 120 Methylphenidate 189 Temazepam
52 Cyclobenzaprine 121 Metoclopramide 190 Tetracaine
53 Desalkyl flurazepam 122 Metoprolol 191 Tetrazepam
54 Desipramine 123 Mianserine 192 TFMPP
55 Desmethylcyclobenzaprine 124 Midazolam 193 Theophylline
56 Dextromethorphan 125 Milnacipran 194 Thioridazine
57 Dextrorphan 126 Mitragynine 195 Tiapride
58 Diazepam 127 Mirtazepine 196 Topiramate
59 Dihydrocodeine 128 Modafinil 197 Tramadol
60 Diltiazem 129 Molsidomine 198 Trazadone
61 Diphenhydramine 130 Morphine 199 Triazolam
62 Disopyramide 131 Nadolol 200 Trifluoperazine
63 Doxepin 132 Nalbuphine 201 Trimipramine
64 Doxylamine 133 Nalorphine 202 Tripolidine
65 Droperidol 134 Naltrexone 203 Venlafaxine
66 Duloxetine 135 Naphazoline 204 Verapamil
67 EDDP 136 Naproxen 205 Zolpidem
68 Ephedrine 137 n-desmethyltramadol 206 Zopiclone
69 Estazolam 138 Nicotine    

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